PDCD1LG2 Q9BQ51

程序性细胞死亡1配体2 (PD-1配体2) (PD-L2) (PDCD1配体2) (程序性死亡配体2) (嗜乳脂蛋白B7-DC) (B7-DC) (CD抗原CD273)

蛋白质信息 (UniProt)

程序性细胞死亡1配体2 (PD-1配体2) (PD-L2) (PDCD1配体2) (程序性死亡配体2) (嗜乳脂蛋白B7-DC) (B7-DC) (CD抗原CD273)

Q9BQ51

功能描述

在诱导和维持对自身的免疫耐受中发挥关键作用 (PubMed:11224527, PubMed:12538684). 作为抑制性受体PDCD1/PD-1的配体，通过阻断细胞周期进程和细胞因子产生来抑制T细胞增殖 (PubMed:11224527). {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:12538684}.

组织特异性

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

亚细胞定位

[Isoform 3]: Secreted

关键词

3D-structure Adaptive immunity Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane

外部链接

UniProt: Q9BQ51

NCBI Gene

GeneCards