PCSK6 P29122

前蛋白转化酶枯草杆菌蛋白酶/kexin 6型 (EC 3.4.21.-) (成对碱性氨基酸裂解酶 4) (枯草杆菌蛋白酶样前蛋白转化酶 4) (SPC4) (枯草杆菌蛋白酶/kexin样蛋白酶 PACE4)

功能描述

丝氨酸内切蛋白酶，通过在成对碱性氨基酸处切割来加工各种前蛋白，识别 RXXX[KR]R 共有序列基序。可能通过组成型分泌途径发挥作用，在神经内分泌和非神经内分泌组织中具有独特的受限分布。

组织特异性

Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.

亚细胞定位

[Isoform PACE4A-I]: Secreted.; SUBCELLULAR LOCATION: [Isoform PACE4A-II]: Secreted.; SUBCELLULAR LOCATION: [Isoform PACE4C]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; SUBCELLULAR LOCATION: [Isoform PACE4CS]: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.; SUBCELLULAR LOCATION: [Isoform PACE4E-I]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; SUBCELLULAR LOCATION: [Isoform PACE4E-II]: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; SUBCELLULAR LOCATION: [Isoform PACE4B]: Secreted.