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PCDH12 Q9NPG4

原钙黏蛋白-12 (血管钙黏蛋白-2) (血管内皮钙黏蛋白-2) (VE-cad-2) (VE-cadherin-2) [切割为:分泌型原钙黏蛋白-12]

蛋白质信息 (UniProt)

原钙黏蛋白-12 (血管钙黏蛋白-2) (血管内皮钙黏蛋白-2) (VE-cad-2) (VE-cadherin-2) [切割为:分泌型原钙黏蛋白-12]

Q9NPG4

功能描述

细胞粘附分子,可能在内皮细胞间连接处的细胞-细胞相互作用中发挥重要作用 (By similarity)。作为细胞迁移的调节因子,可能通过增强细胞-细胞粘附起作用 (PubMed:21402705)。促进同嗜性钙依赖性聚集和粘附,并聚集在细胞间连接处 (By similarity)。不能结合catenins,与细胞骨架微弱关联 (By similarity)。 {ECO:0000250|UniProtKB:O55134, ECO:0000269|PubMed:21402705}。

组织特异性

Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression (PubMed:11063261). Prominent expression in the spleen (PubMed:11063261). Present in villous and extravillous trophoblast (at protein level) (PubMed:21402705).

亚细胞定位

[Protocadherin-12]: Cell membrane

关键词

Calcium Cell adhesion Cell junction Cell membrane Disease variant Epilepsy Glycoprotein Intellectual disability Membrane Phosphoprotein