PATL1 Q86TB9

PAT1同源蛋白1 (PAT1样蛋白1) (PAT1同源蛋白b) (Pat1b) (hPat1b)

蛋白质信息 (UniProt)

PAT1同源蛋白1 (PAT1样蛋白1) (PAT1同源蛋白b) (Pat1b) (hPat1b)

Q86TB9

功能描述

RNA结合蛋白，参与mRNA的去腺苷酸化依赖性脱帽，导致mRNA降解 (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261)。作为支架蛋白，连接去腺苷酸化和脱帽机制 (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261)。细胞质mRNA处理小体(P-body)组装所必需 (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261)。 {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (微生物感染) 在感染情况下，丙型肝炎病毒(HCV)的翻译和复制所必需。 {ECO:0000269|PubMed:19628699}.

组织特异性

Ubiquitous.

亚细胞定位

Cytoplasm, P-body

关键词

3D-structure Alternative splicing Cytoplasm Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding

外部链接

UniProt: Q86TB9

NCBI Gene

GeneCards