PASD1 Q8IV76

生物钟蛋白PASD1 (癌/睾抗原63) (CT63) (OX-TES-1) (含PAS结构域蛋白1)

功能描述

作为抑制因子，抑制驱动全身细胞每日昼夜节律的生物钟 (PubMed:25936801)。作为核抑制因子，抑制CLOCK-BMAL1异二聚体介导的核心时钟组分转录激活 (PubMed:25936801)。在癌细胞中过表达时，抑制生物钟功能 (PubMed:25936801)。 {ECO:0000269|PubMed:25936801}。

组织特异性

Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).

亚细胞定位

[Isoform 1]: Nucleus