β-微蛋白 (Affixin)
β-微蛋白 (Affixin)
Q9HBI1功能描述
作为适配蛋白，通过ILK参与整合素信号传导，并参与鸟嘌呤交换因子（如ARHGEF6）激活GTPase CDC42和RAC1的过程。参与肌动蛋白细胞骨架的重组和片状伪足的形成。在细胞粘附、细胞铺展、细胞极性的建立或维持以及细胞迁移中发挥作用。 {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.
组织特异性
Expressed predominantly in heart and skeletal muscle.
亚细胞定位
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
关键词