PAPPA2 Q9BXP8

妊娠相关血浆蛋白A2 (EC 3.4.24.-) (妊娠相关血浆蛋白A2) (PAPP-A2) (妊娠相关血浆蛋白E1) (PAPP-E)

蛋白质信息 (UniProt)

妊娠相关血浆蛋白A2 (EC 3.4.24.-) (妊娠相关血浆蛋白A2) (PAPP-A2) (妊娠相关血浆蛋白E1) (PAPP-E)

Q9BXP8

功能描述

金属蛋白酶，特异性在 '163-Ser-|-Lys-164' 键处切割胰岛素样生长因子结合蛋白 (IGFBP)-5。对 IGFBP-3 显示有限的蛋白水解。 {ECO:0000269|PubMed:11264294, ECO:0000269|PubMed:26902202}。

组织特异性

Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.

亚细胞定位

Secreted

关键词

3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Dwarfism Glycoprotein Hydrolase Metal-binding Metalloprotease

外部链接

UniProt: Q9BXP8

NCBI Gene

GeneCards