妊娠相关血浆蛋白A-1 (EC 3.4.24.79) (胰岛素样生长因子依赖性IGF结合蛋白4蛋白酶) (IGF依赖性IGFBP-4蛋白酶) (IGFBP-4酶) (妊娠相关血浆蛋白A) (PAPP-A)
妊娠相关血浆蛋白A-1 (EC 3.4.24.79) (胰岛素样生长因子依赖性IGF结合蛋白4蛋白酶) (IGF依赖性IGFBP-4蛋白酶) (IGFBP-4酶) (妊娠相关血浆蛋白A) (PAPP-A)
Q13219功能描述
金属蛋白酶，特异性裂解IGFBP-4和IGFBP-5，导致结合的IGF释放。IGF的存在显著增强IGFBP-4的裂解，而IGF的存在轻微抑制IGFBP-5的裂解。 {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:11522292}.
组织特异性
High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
亚细胞定位
Secreted
关键词