P抗原家族成员4 (PAGE-4) (G抗原家族C成员1) (PAGE-1)
P抗原家族成员4 (PAGE-4) (G抗原家族C成员1) (PAGE-1)
O60829功能描述
固有无序蛋白，增强JUN的转录激活因子活性 (PubMed:24263171, PubMed:28289210)。通过抑制活性氧 (ROS) 产生以及通过调节MAPK信号通路，保护细胞免受应激诱导的凋亡 (PubMed:21357425, PubMed:25374899, PubMed:30658679)。 {ECO:0000269|PubMed:21357425, ECO:0000269|PubMed:24263171, ECO:0000269|PubMed:25374899, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:30658679}。
组织特异性
Expressed at basal lvels in the adult normal prostate gland but is highly up-regulated in the fetal prostate and prostate cancer cells (PubMed:12489849, PubMed:24263171, PubMed:24559171, PubMed:25374899). Preferentially expressed in normal male and female reproductive tissues, testis, fallopian tube, uterus, and placenta, as well as in testicular cancer, uterine cancer, cervical cancer and kidney cancer (PubMed:12489849, PubMed:9724777).
亚细胞定位
Cytoplasm
关键词