PACRG Q96M98

Parkin共调节基因蛋白 (分子伴侣/伴侣蛋白结合蛋白) (PARK2共调节基因蛋白)

功能描述

纤毛轴丝中动力蛋白装饰的双微管(DMTs)的微管内蛋白(MIP)部分，这是运动性纤毛摆动所必需的 (PubMed:36191189)。抑制由未折叠Pael受体(Pael-R，Parkin的底物)积累诱导的细胞死亡 (PubMed:14532270)。当蛋白酶体被抑制时，促进由Pael-R、分子伴侣、蛋白降解分子及其自身组成的包涵体的形成 (PubMed:14532270)。可能在路易小体的形成和保护多巴胺能神经元免受帕金森病侵害方面发挥重要作用 (PubMed:14532270)。 {ECO:0000269|PubMed:14532270, ECO:0000269|PubMed:36191189}。

组织特异性

Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.

亚细胞定位

Cytoplasm, cytoskeleton, cilium axoneme