OR51E2 Q9H255

嗅觉受体 51E2 (HPRAJ) (嗅觉受体 OR11-16) (前列腺特异性G蛋白偶联受体)

功能描述

嗅觉受体 (PubMed:27226631, PubMed:29249973)。被气味物质β-紫罗兰酮（一种合成萜类化合物）激活 (PubMed:19389702, PubMed:27226631, PubMed:29249973)。该受体的活性可能由G蛋白介导，导致细胞内Ca(2+)和cAMP升高，并激活蛋白激酶PKA和MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973)。β-紫罗兰酮刺激OR51E2影响黑素细胞的增殖、分化和黑素生成 (PubMed:27226631)。β-紫罗兰酮激活OR51E2增加原代视网膜色素上皮(RPE)细胞的增殖和迁移 (PubMed:29249973)。也可被短链脂肪酸(SCFA)乙酸和丙酸激活。响应SCFA，可能正调节肾素分泌并增加血压 (PubMed:23401498)。也可能被类固醇激素激活并调节细胞增殖 (PubMed:19389702)。在球状细胞中被L-乳酸激活 (By similarity)。 {ECO:0000250|UniProtKB:Q8VBV9, ECO:0000269|PubMed:19389702, ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973}。

组织特异性

Highly expressed in the prostate (PubMed:11707321). Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:11707321, PubMed:16491480, PubMed:29249973). In the retinal pigment epithelium expression is restricted to the pigment cells and choroid (at protein level) (PubMed:29249973). Expressed in epidermal melanocytes (at protein level) (PubMed:27226631).

亚细胞定位

Cell membrane