OLFML3 Q9NRN5

类嗅质蛋白3 (HNOEL-iso) (hOLF44)

功能描述

分泌型支架蛋白，在早期发育过程中的背腹图式形成中发挥重要作用。通过限制背侧chordin (CHRD)的活性来稳定轴的形成。通过促进tolloid蛋白酶与其底物chordin (CHRD)之间的结合发挥作用，从而增强chordin (CHRD)的降解 (By similarity)。可能具有涉及胎盘和胚胎发育的基质相关功能，或在其他生理过程中发挥类似作用。 {ECO:0000250, ECO:0000269|PubMed:15280020}。

组织特异性

Abundant in placenta, moderate in liver and heart, whereas fairly weak in other tissues examined. On term placenta, mainly localized extracellularly surrounding the syncytiotrophoblastic cells and very rarely expressed in the maternal decidua layer.

亚细胞定位

Secreted