动粒蛋白Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (细胞分裂周期相关蛋白1)
动粒蛋白Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (细胞分裂周期相关蛋白1)
Q9BZD4功能描述
作为必需的动粒相关NDC80复合物的组分起作用，该复合物是染色体分离和纺锤体检查点活性所必需的 (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814)。为动粒完整性以及动粒外板上稳定微管结合位点的组织所必需 (PubMed:15548592)。NDC80复合物协同增强SKA1复合物对微管的亲和力，并可能允许NDC80复合物追踪解聚微管 (PubMed:23085020)。 {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23085020}。
亚细胞定位
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.
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