NR3C2 P08235

盐皮质激素受体 (MR) (核受体亚家族3 C组成员2)

功能描述

盐皮质激素(MC)（如醛固酮）和糖皮质激素(GC)（如皮质酮或皮质醇）的受体。结合盐皮质激素应答元件(MRE)并反式激活靶基因。MC的作用是增加离子和水转运，从而增加细胞外液容量和血压，并降低钾水平。{ECO:0000269|PubMed:3037703}。

组织特异性

Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.

亚细胞定位

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.