NPVF Q9HCQ7

前FMRF酰胺相关神经肽VF [裂解为：神经肽NPSF；神经肽RFRP-1；神经肽RFRP-2；神经肽NPVF (神经肽RFRP-3)]

蛋白质信息 (UniProt)

前FMRF酰胺相关神经肽VF [裂解为：神经肽NPSF；神经肽RFRP-1；神经肽RFRP-2；神经肽NPVF (神经肽RFRP-3)]

Q9HCQ7

功能描述

[Neuropeptide RFRP-1]: 有效抑制毛喉素诱导的cAMP产生。作为促性腺激素合成和分泌的强效负调节因子 (PubMed:11025660, PubMed:20027225)。诱导催乳素分泌 (By similarity)。 {ECO:0000250|UniProtKB:Q9ESQ9, ECO:0000269|PubMed:11025660, ECO:0000269|PubMed:20027225}.; FUNCTION: [Neuropeptide NPVF]: 有效抑制毛喉素诱导的cAMP产生。阻断吗啡诱导的镇痛。 {ECO:0000269|PubMed:11025660, ECO:0000269|PubMed:20027225}.; FUNCTION: [Neuropeptide RFRP-2]: 对毛喉素诱导的cAMP产生无抑制活性。 {ECO:0000269|PubMed:11025660}.

组织特异性

[Isoform 1]: Specifically expressed in the retina.

亚细胞定位

Secreted

关键词

Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Neuropeptide Proteomics identification Reference proteome Secreted Signal

外部链接

UniProt: Q9HCQ7

NCBI Gene

GeneCards