NPSR1 Q6W5P4

神经肽S受体 (G蛋白偶联受体154) (G蛋白偶联受体PGR14) (哮喘易感性G蛋白偶联受体)

功能描述

神经肽S (NPS)的G蛋白偶联受体 (PubMed:15947423, PubMed:16720571, PubMed:16790440)。受体被NPS激活后启动G(q)/GNAQ依赖的磷脂酶C激活信号通路，导致Ca(2+)从胞内库动员并增加胞内Ca(2+)水平 (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440, PubMed:25714705, PubMed:26865629)。除该通路外，NPS与其受体结合激活cAMP/PKA信号转导 (PubMed:26865629)。最终，这两条通路汇聚以激活ERK1/ERK2磷酸化和信号级联反应 (PubMed:26865629)。响应NPS结合抑制细胞生长 (PubMed:15947423)。 {ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16720571, ECO:0000269|PubMed:16790440, ECO:0000269|PubMed:25714705, ECO:0000269|PubMed:26865629}。

组织特异性

Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.

亚细胞定位

[Isoform 1]: Cell membrane