神经肽FF受体2 (G蛋白偶联受体74) (G蛋白偶联受体HLWAR77) (神经肽G蛋白偶联受体)
神经肽FF受体2 (G蛋白偶联受体74) (G蛋白偶联受体HLWAR77) (神经肽G蛋白偶联受体)
Q9Y5X5功能描述
NPAF (A-18-F-amide) 和 NPFF (F-8-F-amide) 神经肽的受体，也称为吗啡调节肽。也可被多种天然存在或合成的 FMRF-amide 样配体激活。该受体通过与 G 蛋白结合介导其作用，激活磷脂酰肌醇-钙第二信使系统。 {ECO:0000269|PubMed:11024015}。
组织特异性
Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas.
亚细胞定位
Cell membrane
关键词