NMU P48645

神经介素-U [裂解为：神经介素前体相关肽 36 (NURP36)；神经介素前体相关肽 33 (NURP33)；神经介素-U-25 (NmU-25)]

蛋白质信息 (UniProt)

神经介素-U [裂解为：神经介素前体相关肽 36 (NURP36)；神经介素前体相关肽 33 (NURP33)；神经介素-U-25 (NmU-25)]

P48645

功能描述

[Neuromedin-U-25]: 受体NMUR1和NMUR2的配体 (By similarity)。刺激胃肠道特定区域的肌肉收缩。在人类中，NmU刺激回肠和膀胱的收缩。 {ECO:0000250|UniProtKB:P12760}.; FUNCTION: [Neuromedin precursor-related peptide 33]: 不作为NMUR1或NMUR2的配体起作用。间接诱导催乳素释放，尽管其效力远低于neuromedin precursor-related peptide 36。 {ECO:0000250|UniProtKB:P12760}.; FUNCTION: [Neuromedin precursor-related peptide 36]: 不作为NMUR1或NMUR2的配体起作用。间接诱导垂体催乳素细胞释放催乳素，可能通过下丘脑多巴胺能系统。 {ECO:0000250|UniProtKB:P12760}.

组织特异性

Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

亚细胞定位

Secreted.

关键词

3D-structure Amidation Cleavage on pair of basic residues Neuropeptide Oxidation Proteomics identification Reference proteome Secreted Signal

外部链接

UniProt: P48645

NCBI Gene

GeneCards