含NACHT、LRR和PYD结构域蛋白10 (核苷酸结合寡聚化结构域蛋白8)
含NACHT、LRR和PYD结构域蛋白10 (核苷酸结合寡聚化结构域蛋白8)
Q86W26功能描述
抑制CASP1的自加工、依赖CASP1的IL1B分泌、PYCARD聚集以及PYCARD介导的细胞凋亡，但不抑制由FAS或BID诱导的细胞凋亡 (PubMed:15096476)。表现出抗炎活性 (PubMed:20393137)。抗白色念珠菌（C.albicans）感染免疫所必需 (By similarity)。参与先天免疫反应，通过促进侵入性细菌感染引起的促炎细胞因子释放发挥作用 (PubMed:22672233)。促进皮肤中T细胞介导的炎症反应 (By similarity)。通过参与感染牙周病原体的口腔上皮细胞中经由ERK激活诱导IL1A，在预防牙周炎中发挥作用 (PubMed:28766990)。具有ATP酶和GTP酶活性 (PubMed:23861819)。 {ECO:0000250|UniProtKB:Q8CCN1, ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:20393137, ECO:0000269|PubMed:22672233, ECO:0000269|PubMed:23861819}。
组织特异性
Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) (PubMed:22672233). Widely expressed with highest levels in heart, brain and skeletal muscle (PubMed:15096476). Also expressed in liver, colon, dermis and epidermis (PubMed:15096476). Little expression detected in myeloid cells or peripheral blood mononuclear cells (PubMed:15096476).
亚细胞定位
Cytoplasm
关键词