NKG7 Q16617

NKG7蛋白 (G-CSF诱导基因1蛋白) (GIG-1蛋白) (17 kDa颗粒膜蛋白) (GMP-17) (自然杀伤细胞蛋白7) (p15-TIA-1)

功能描述

调节效应淋巴细胞的细胞毒性颗粒胞吐，从而作为多种感染性和非感染性疾病炎症的关键介质 (By similarity)。对于自然杀伤 (NK) 细胞和 CD8(+) T细胞的细胞毒性脱颗粒以及感染后 CD4(+) T细胞的激活至关重要 (By similarity)。在 CD8(+) T细胞和 NK细胞介导的靶细胞裂解中起关键作用，并通过增强携带 LAMP1 的溶解颗粒的胞吐，经由穿孔蛋白/颗粒酶途径促进细胞溶解活性 (By similarity)。有助于 NK细胞介导的癌症转移控制 (By similarity)。 {ECO:0000250|UniProtKB:Q99PA5}。

组织特异性

Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

亚细胞定位

Cell membrane