NISCH Q9Y2I1

Nischarin (咪唑啉受体1) (I-1) (IR1) (咪唑啉受体抗血清选定蛋白) (hIRAS) (咪唑啉-1受体) (I1R) (咪唑啉-1受体候选蛋白) (I-1受体候选蛋白) (I1R候选蛋白)

功能描述

作为功能性咪唑啉-1受体（I1R）候选者或I1R信号传导的膜相关介质发挥作用。结合多种咪唑啉配体，诱导启动细胞信号级联反应，从而触发细胞存活、生长和迁移。其被激动剂rilmenidine激活后，诱导延髓头端腹外侧区（RVLM）神经元中丝裂原活化蛋白激酶MAPK1和MAPK3的磷酸化增加，这些神经元表现出rilmenidine诱发的低血压（By similarity）。用efaroxan阻断其激活可消除RVLM神经元中rilmenidine诱导的丝裂原活化蛋白激酶磷酸化（By similarity）。作为Rac调节的信号转导通路的调节因子发挥作用（By similarity）。通过与PAK1相互作用并抑制其激酶活性，从而抑制Rac1刺激的细胞迁移（By similarity）。还通过与RAC1相互作用并抑制Rac1刺激的NF-kB反应元件和细胞周期蛋白D1启动子激活，从而阻断不依赖Pak的Rac信号传导（By similarity）。还通过减少LIMK1 'Tyr-508' 磷酸化来抑制LIMK1激酶活性（By similarity）。抑制乳腺和结肠上皮细胞中Rac诱导的细胞迁移和侵袭（By similarity）。过表达时，抑制片状伪足形成（By similarity）。在抗凋亡保护中发挥作用。参与与IRS4联合增强胰岛素对MAPK1和MAPK3的激活。过表达时，诱导细胞表面ITGA5整合素重分布至胞内内体结构。 {ECO:0000250, ECO:0000269|PubMed:10882231, ECO:0000269|PubMed:12868002, ECO:0000269|PubMed:15028619, ECO:0000269|PubMed:15028621, ECO:0000269|PubMed:15475348}。

组织特异性

Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.

亚细胞定位

Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Note=Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity).