NINL Q9Y2I6

Ninein样蛋白

功能描述

参与间期细胞中的微管组织。过表达诱导高尔基体碎片化，并导致溶酶体向细胞周边分散；它还干扰有丝分裂纺锤体组装。参与光感受器细胞中的囊泡运输（根据相似性）。可能在卵巢致癌过程中发挥作用。 {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}。

组织特异性

Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeletal muscle, liver, lung and cochlea, and in adult brain, testis, kidney and retina.

亚细胞定位

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome