神经损伤诱导蛋白-2 (神经损伤诱导蛋白 2)
神经损伤诱导蛋白-2 (神经损伤诱导蛋白 2)
Q9NZG7功能描述
其作用尚不明确 (PubMed:33472215, PubMed:38614101, PubMed:39667936)。与NINJ1旁系同源物相反，不介导坏死性凋亡和细胞焦亡程序性细胞死亡下游的质膜破裂（细胞溶解） (PubMed:33472215, PubMed:38614101, PubMed:39667936)。虽然它能够寡聚化并形成丝状体，但丝状体向细胞内空间弯曲，阻止了介导质膜破裂的环化 (PubMed:39667936)。可能作为参与神经再生的同嗜性跨膜粘附分子起作用 (PubMed:10627596)。促进轴突生长 (PubMed:10627596)。 {ECO:0000269|PubMed:10627596, ECO:0000269|PubMed:33472215, ECO:0000269|PubMed:38614101, ECO:0000269|PubMed:39667936}。
组织特异性
Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney.
亚细胞定位
Cell membrane
关键词