NHS Q6T4R5

肌动蛋白重塑调节因子NHS (先天性白内障和牙齿异常蛋白) (Nance-Horan综合征蛋白)

功能描述

可能通过维持环状actin环的完整性和控制片状伪足形成而在细胞形态中发挥作用。参与眼睛、牙齿、大脑和颅面发育的调节。 {ECO:0000269|PubMed:20332100}。

组织特异性

Detected at low levels in all tissues analyzed. Detected in fetal and adult brain, lens, retina, retinal pigment epithelium, placenta, lymphocytes and fibroblasts. Levels in retinal pigment epithelium, placenta, lymphocytes, and fibroblasts are very low. Expressed also in kidney, lung and thymus.

亚细胞定位

[Isoform 1]: Apical cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, tight junction. Cell junction, focal adhesion. Note=Colocalizes with the tight junction protein TJP1 in epithelial cells. Localizes to the leading edge of lamellipodia in motile cells.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.