NFKBIE O00221

NF-kappa-B抑制蛋白epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)

功能描述

将NF-kappa-B转录因子复合物隔离在细胞质中，从而抑制其活性 (PubMed:9315679)。被隔离的复合物包括NFKB1-RELA (p50-p65) 和NFKB1-REL (p50-c-Rel) 复合物 (PubMed:9135156, PubMed:9315679)。限制B细胞对病原体的反应激活，并在B细胞发育中发挥重要作用 (By similarity)。 {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}。

组织特异性

Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.

亚细胞定位

Cytoplasm