NFATC4 Q14934

活化T细胞核因子，胞质4 (NF-ATc4) (NFATc4) (T细胞转录因子NFAT3) (NF-AT3)

功能描述

Ca(2+)调节的转录因子，参与多种过程，包括免疫、心血管、肌肉骨骼和神经系统的发育与功能 (PubMed:11514544, PubMed:11997522, PubMed:17213202, PubMed:17875713, PubMed:18668201, PubMed:25663301, PubMed:7749981)。参与T细胞活化，刺激细胞因子基因的转录，包括IL2和IL4的基因 (PubMed:18347059, PubMed:18668201, PubMed:7749981)。与NFATC3一起，参与胚胎心脏发育。在JAK/STAT信号激活后，作为与NFATC3和STAT3复合物的一部分，结合CRYAB的alpha-beta E4启动子区域并激活心肌细胞的转录 (By similarity)。参与心脏形态发生和功能所需的线粒体能量代谢 (By similarity)。反式激活许多心血管系统相关基因，包括AGTR2、NPPB/BNP（与GATA4协同作用）、NPPA/ANP/ANF和MYH7/beta-MHC (By similarity)。参与成年海马神经发生的调节。参与海马成年新生神经元中BDNF驱动的促存活信号传导。参与长期空间记忆和长期增强的形成 (By similarity)。在耳蜗核神经元中，可能在发育关键期去神经支配诱导的细胞凋亡中发挥作用，此时听觉神经元的存活依赖于传入输入 (By similarity)。结合并激活BACE1/Beta-secretase 1启动子，因此可能调节淀粉样前体蛋白 (APP) 的蛋白水解加工 (PubMed:25663301)。在脂肪细胞分化中发挥作用 (PubMed:11997522)。可能参与成肌细胞分化为肌管的过程 (PubMed:17213202)。结合共有DNA序列5'-GGAAAAT-3' (Probable)。在CREBBP存在下，激活TNF转录 (PubMed:11514544)。结合PPARG基因启动子并调节其活性 (PubMed:11997522)。结合PPARG和REG3G基因启动子 (By similarity)。 {ECO:0000250|UniProtKB:D3Z9H7, ECO:0000250|UniProtKB:Q8K120, ECO:0000269|PubMed:11514544, ECO:0000269|PubMed:11997522, ECO:0000269|PubMed:17213202, ECO:0000269|PubMed:17875713, ECO:0000269|PubMed:18347059, ECO:0000269|PubMed:18668201, ECO:0000269|PubMed:25663301, ECO:0000269|PubMed:7749981, ECO:0000305}。

组织特异性

Widely expressed, with high levels in placenta, lung, kidney, testis and ovary (PubMed:18675896). Weakly expressed in spleen and thymus (PubMed:18675896). In the hippocampus, expressed in the granular layer of the dentate gyrus, in the pyramidal neurons of CA3 region, and in the hippocampal fissure (PubMed:18675896). Expressed in the heart (at protein level) (PubMed:12370307).

亚细胞定位

Cytoplasm