活化T细胞核因子，胞质2 (NF-ATc2) (NFATc2) (NFAT预存亚基) (NF-ATp) (T细胞转录因子NFAT1)
活化T细胞核因子，胞质2 (NF-ATc2) (NFATc2) (NFAT预存亚基) (NF-ATp) (T细胞转录因子NFAT1)
Q13469功能描述
在T细胞中细胞因子基因的诱导表达中发挥作用，特别是在IL-2、IL-3、IL-4、TNF或GM-CSF的诱导中 (PubMed:15790681)。通过激活GPC6表达和WNT5A信号通路促进侵袭性迁移 (PubMed:21871017)。参与软骨形成的负调控 (PubMed:35789258)。被AKAP5募集到CRAC通道的ORAI1孔形成亚基，位于Ca(2+)信号微结构域中，在此处库操纵性Ca(2+)内流与钙调蛋白和钙调磷酸酶信号传导以及NFAT依赖性转录反应的激活相偶联。 {ECO:0000250|UniProtKB:Q60591, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:21871017, ECO:0000269|PubMed:35789258}。
组织特异性
Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid.
亚细胞定位
Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
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