NEURL1B A8MQ27

E3泛素蛋白连接酶NEURL1B (EC 2.3.2.27) (Neuralized-2) (NEUR2) (Neuralized样蛋白1B) (Neuralized样蛋白3) (RING型E3泛素转移酶NEURL1B)

功能描述

E3泛素-蛋白连接酶，通过影响几种Notch配体的稳定性和活性参与Notch通路的调节。 {ECO:0000269|PubMed:19723503}。

组织特异性

Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe.

亚细胞定位

Cytoplasm