负延伸因子A (NELF-A) (Wolf-Hirschhorn综合征候选蛋白2)
负延伸因子A (NELF-A) (Wolf-Hirschhorn综合征候选蛋白2)
Q9H3P2功能描述
NELF复合物的必需组分，该复合物负调控RNA polymerase II的转录延伸。NELF复合物通过与DSIF复合物结合发挥作用并导致转录暂停，其作用被P-TEFb激酶复合物拮抗。 {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) NELF复合物参与HIV-1潜伏期，可能涉及将PCF11募集到暂停的RNA polymerase II。 {ECO:0000269|PubMed:23884411}.
组织特异性
Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.
亚细胞定位
Nucleus
关键词