丝氨酸/苏氨酸蛋白激酶Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA相关蛋白激酶6) (蛋白激酶SID6-1512)
丝氨酸/苏氨酸蛋白激酶Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA相关蛋白激酶6) (蛋白激酶SID6-1512)
Q9HC98功能描述
蛋白激酶，在有丝分裂细胞周期进程中发挥重要作用 (PubMed:11516946, PubMed:14563848)。为中期-后期转换时的染色体分离、稳健的有丝分裂纺锤体形成和胞质分裂所必需 (PubMed:19414596)。磷酸化ATF4、CIRSR、PTN、RAD26L、RBBP6、RPS7、RPS6KB1、TRIP4、STAT3以及组蛋白H1和H3 (PubMed:12054534, PubMed:20873783)。磷酸化KIF11以促进有丝分裂纺锤体形成 (PubMed:19001501)。参与DNA损伤诱导的G2/M期细胞周期停滞 (PubMed:18728393)。抑制其活性会导致细胞凋亡。可能通过抑制p53/TP53诱导的癌细胞衰老从而促进肿瘤发生 (PubMed:21099361)。磷酸化EML4的'Ser-144'，促进其在有丝分裂期间与微管解离，这是有效染色体中板集合所必需的 (PubMed:31409757)。 {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}。
组织特异性
Ubiquitous, with highest expression in heart and skeletal muscle.
亚细胞定位
Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIRSR, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.
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