NDRG2 Q9UN36

NDRG2蛋白 (N-myc下游调节基因2蛋白) (Syld709613蛋白)

功能描述

参与Wnt信号通路的调节。下调CTNNB1介导的靶基因（如CCND1）转录激活，并可能因此作为肿瘤抑制因子发挥作用。可能参与树突状细胞和神经元分化。 {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.

组织特异性

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).

亚细胞定位

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone