NDRG1 Q92597

NDRG1蛋白 (分化相关基因1蛋白) (DRG-1) (N-myc下游调节基因1蛋白) (镍特异性诱导蛋白Cap43) (还原剂和衣霉素响应蛋白) (RTP) (Rit42)

功能描述

应激响应蛋白，参与激素反应、细胞生长和分化。在多种细胞类型中作为肿瘤抑制因子发挥作用。是p53/TP53介导的caspase激活和细胞凋亡的必要但不充分条件。参与细胞运输，特别是施万细胞的运输，是外周神经髓鞘维持和发育所必需的。CDH1和TF的囊泡循环所必需。可能也参与脂质运输功能。保护细胞免受纺锤体损伤。在p53/TP53依赖性有丝分裂纺锤体检查点中发挥作用。调节微管动力学并维持整倍性。 {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}。

组织特异性

Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.

亚细胞定位

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.