NCKAP1 Q9Y2A7

Nck相关蛋白1 (NAP 1) (膜相关蛋白HEM-2) (p125Nap1)

功能描述

WAVE复合物的一部分，调节片状伪足形成。WAVE复合物通过与Arp2/3复合物相互作用调节肌动蛋白丝重组。肌动蛋白重塑活性受RAC1调节。作为WAVE1复合物的组分，是BDNF-NTRK2内吞运输和早期内体信号传导所必需的。 {ECO:0000250|UniProtKB:P28660}。

组织特异性

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle. Expressed in cells of various brain regions including Purkinje cells and dentate nucleus of the cerebellum, CA4 region and dentate gyrus of the hippocampus, and in frontal gray and white matter (PubMed:28940097).

亚细胞定位

Cell membrane