Nanos同源物3 (NOS-3)
Nanos同源物3 (NOS-3)
P60323功能描述
在维持生殖细胞未分化状态中发挥作用，调节精原细胞周期并诱导G1期滞留延长。可能通过抑制特定mRNA的翻译来影响细胞增殖。通过抑制Bax依赖性和非依赖性凋亡途径维持生殖细胞谱系。在早期胚胎阶段对于保护迁移中的原始生殖细胞(PGCs)免于凋亡至关重要。 {ECO:0000269|PubMed:21421998}。
组织特异性
Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.
亚细胞定位
Nucleus
关键词