MYOCD Q8IZQ8

心肌素

功能描述

平滑肌细胞 (SM) 和心肌细胞特异性转录因子，利用典型的单个或多个CArG box DNA序列。作为血清反应因子 (SRF) 的辅因子，具有调节SRF靶基因的潜能。在心脏发生、膀胱发育和平滑肌细胞谱系分化（肌发生）中起关键作用 (By similarity)。正向调节涉及血管平滑肌收缩的基因转录 (By similarity)。 {ECO:0000250, ECO:0000250|UniProtKB:Q8R5I7, ECO:0000269|PubMed:12640126, ECO:0000269|PubMed:31513549}。

组织特异性

Expressed in the heart, aorta and bladder (PubMed:12640126, PubMed:20385216). Expressed in smooth muscle cell-containing tissues: stomach, small intestine, colon, lung, placenta and uterus (PubMed:12640126). Very faint expression in prostate and skeletal muscle (PubMed:12640126).

亚细胞定位

Nucleus