基质重塑相关蛋白5 (与基底膜蛋白聚糖相关的富含亮氨酸重复序列和免疫球蛋白结构域的黏附蛋白) (Adlican)
基质重塑相关蛋白5 (与基底膜蛋白聚糖相关的富含亮氨酸重复序列和免疫球蛋白结构域的黏附蛋白) (Adlican)
Q9NR99功能描述
在肾脏中，具有抗炎和抗纤维化特性，通过限制响应TGB1和促炎刺激而诱导的趋化因子、纤连蛋白和胶原蛋白表达。 {ECO:0000269|PubMed:27599751}。
组织特异性
Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid and fibroblasts (at protein level) (PubMed:25326458, PubMed:36213313). Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751).
亚细胞定位
Secreted
关键词