MUC20 Q8N307

黏蛋白-20 (MUC-20)

功能描述

可能调节MET信号级联反应。似乎减弱肝细胞生长因子(HGF)诱导的短暂MAPK激活。阻断GRB2向MET的募集，从而抑制GRB2-RAS通路。抑制HGF诱导的MMP1和MMP9表达的增殖。 {ECO:0000269|PubMed:15314156}。

组织特异性

Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.

亚细胞定位

Secreted