MUC16 Q8WXI7

黏蛋白-16 (MUC-16) (卵巢癌相关肿瘤标志物CA125) (CA-125) (卵巢癌抗原CA125)

功能描述

推测在粘膜表面提供针对颗粒和感染因子的保护性润滑屏障。 {ECO:0000250}。

组织特异性

Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.

亚细胞定位

Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.