MSMP Q1L6U9

前列腺相关微量精浆蛋白 (PC3分泌微量蛋白)

功能描述

作为C-C趋化因子受体CCR2的配体 (PubMed:24442440)。通过结合并激活CCR2进行信号传导，并诱导强烈的趋化反应和细胞内钙离子动员 (PubMed:24442440)。对单核细胞和淋巴细胞表现出趋化活性，但对中性粒细胞无趋化活性 (PubMed:24442440)。 {ECO:0000269|PubMed:24442440}。

组织特异性

Detected in prostate epithelium (at protein level) (PubMed:17338636). Detected in trachea and testis (PubMed:17338636). Highly expressed in benign prostatic hyperplasia and in some prostate cancers, and can also be detected in breast tumor tissue (PubMed:17338636, PubMed:24442440).

亚细胞定位

Secreted