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MPLKIP Q8TAP9

M期特异性PLK1相互作用蛋白 (TTD非光敏1蛋白)

蛋白质信息 (UniProt)

M期特异性PLK1相互作用蛋白 (TTD非光敏1蛋白)

Q8TAP9

功能描述

可能通过调节有丝分裂或胞质分裂在维持细胞周期完整性中发挥作用。 {ECO:0000269|PubMed:17310276}。

组织特异性

Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles.

亚细胞定位

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.

关键词

Cell cycle Cell division Cytoplasm Cytoskeleton Disease variant Methylation Mitosis Nucleus Phosphoprotein Proteomics identification