MPEG1 Q2M385

巨噬细胞表达基因1蛋白 (巨噬细胞基因1蛋白) (Mpg-1) (穿孔蛋白-2) (P-2) [切割为：巨噬细胞表达基因1蛋白，加工形式]

功能描述

参与先天免疫和适应性免疫的孔形成蛋白 (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:31537793, PubMed:33224153)。通过在含抗原的区室中形成孔，促进抗原递送以进行交叉呈递，从而在树突状细胞的抗原交叉呈递中发挥核心作用 (By similarity)。也参与细菌感染后的先天免疫反应；对广谱革兰氏阳性菌、革兰氏阴性菌和抗酸菌表现出抗菌活性 (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:33224153)。通过抑制宿主细胞吞噬泡的酸化，限制细菌从液泡转位到细胞质，从而降低胞质内病原体单核细胞增生李斯特菌的存活率 (By similarity)。活性氧和一氧化氮的抗菌活性所必需的 (By similarity)。 {ECO:0000250|UniProtKB:A1L314, ECO:0000269|PubMed:23753625, ECO:0000269|PubMed:26402460, ECO:0000269|PubMed:28422754, ECO:0000269|PubMed:30609079, ECO:0000269|PubMed:31537793, ECO:0000269|PubMed:33224153}.; FUNCTION: [巨噬细胞表达基因1蛋白，加工形式]: 孔形成蛋白，通过介导抗原递送以进行交叉呈递，在树突状细胞的抗原交叉呈递中发挥核心作用 (By similarity)。树突状细胞通过捕获MHC I类分子上的外源性抗原并将其呈递给初始CD8(+) T细胞，从而连接先天免疫和适应性免疫 (By similarity)。通过在含抗原的区室中形成孔发挥作用，促进抗原释放到细胞质中，从而能够生成MHC I:肽复合物并启动T细胞 (By similarity)。 {ECO:0000250|UniProtKB:A1L314}.

组织特异性

Expressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes (PubMed:26402460, PubMed:28705375, PubMed:7888681). In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell types including keratinocytes, fibroblasts and endothelial cells (PubMed:30609079).

亚细胞定位

[Isoform 1]: Cytoplasmic vesicle membrane