MORC4 Q8TE76

MORC家族CW型锌指蛋白4 (锌指CW型卷曲螺旋结构域蛋白2) (锌指CW型结构域蛋白4)

功能描述

组蛋白甲基化阅读器，结合组蛋白H3上非甲基化(H3K4me0)、单甲基化(H3K4me1)、二甲基化(H3K4me2)和三甲基化(H3K4me3)的'Lys-4' (PubMed:26933034)。结合偏好顺序为 H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)。 {ECO:0000269|PubMed:26933034}。

组织特异性

Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.

亚细胞定位

Nucleus