MNDA P41218

髓系细胞核分化抗原

功能描述

可能在髓系细胞谱系中作为转录激活因子/抑制因子发挥作用。在粒细胞/单核细胞对干扰素的特异性反应中起作用。刺激转录抑制蛋白YY1的DNA结合。

组织特异性

Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appears in myeloblast cells in some cases of acute myeloid Leukemia.

亚细胞定位

Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.