胶原酶3 (EC 3.4.24.-) (基质金属蛋白酶-13) (MMP-13)
胶原酶3 (EC 3.4.24.-) (基质金属蛋白酶-13) (MMP-13)
P45452功能描述
在细胞外基质蛋白（包括原纤维胶原蛋白、纤连蛋白、TNC和ACAN）的降解中发挥作用。切割三螺旋胶原蛋白，包括I型、II型和III型胶原蛋白，但对可溶性II型胶原蛋白的活性最高。也能降解IV型、XIV型和X型胶原蛋白。可能还通过激活或降解关键调节蛋白（如TGFB1和CCN2）发挥作用。在伤口愈合、组织重塑、软骨降解、骨骼发育、骨矿化和骨化中发挥作用。正常的胚胎骨骼发育和骨化所必需。通过软骨内骨化在骨折愈合中发挥作用。在伤口愈合中发挥作用，可能通过涉及TGFB1蛋白水解激活和CCN2降解的机制。在伤口愈合过程中的角质形成细胞迁移中发挥作用。可能在细胞迁移和肿瘤细胞侵袭中发挥作用。 {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:19615667, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:8603731, ECO:0000269|PubMed:8663255, ECO:0000269|PubMed:9065415}。
组织特异性
Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue.
亚细胞定位
Secreted, extracellular space, extracellular matrix
关键词