碳水化合物反应元件结合蛋白 (ChREBP) (D类碱性螺旋-环-螺旋蛋白14) (bHLHd14) (MLX相互作用因子) (MLX相互作用蛋白样) (WS碱性螺旋-环-螺旋亮氨酸拉链蛋白) (WS-bHLH) (威廉姆斯-贝伦综合征染色体区域14蛋白)
碳水化合物反应元件结合蛋白 (ChREBP) (D类碱性螺旋-环-螺旋蛋白14) (bHLHd14) (MLX相互作用因子) (MLX相互作用蛋白样) (WS碱性螺旋-环-螺旋亮氨酸拉链蛋白) (WS-bHLH) (威廉姆斯-贝伦综合征染色体区域14蛋白)
Q9NP71功能描述
葡萄糖响应性转录激活因子，调节脂肪酸合成和糖酵解。系统性胰岛素敏感性和葡萄糖稳态的关键决定因子。对于脂肪酸合成酶的表达很重要，包括 PC/Pcx、APOC4/Acl、ACACA/Acc1 和 FASN/Fas (By similarity)。对于葡萄糖诱导的 L-型丙酮酸激酶/PKLR 的表达很重要 (By similarity)。结合典型的和非典型的 E box DNA 序列 5'-CACGTG-3' 和 5'-CACGCG-3' (By similarity)。也可能作为转录抑制因子 (By similarity)。 {ECO:0000250|UniProtKB:Q8VIP2, ECO:0000250|UniProtKB:Q99MZ3}。
组织特异性
Widely expressed with high levels in heart, brain, placenta, skeletal muscle and pancreas. Also expressed in fetal kidney, lung, liver and brain (PubMed:9860302). Expressed in fetal and adult liver (PubMed:10780788). Expressed in the cerebral cortex, including in the frontal, temporal, parietal and occipital lobes, and the cerebellum. Also detected in the intestine, including jejunum, ileum and colon (PubMed:11230181).
亚细胞定位
Cytoplasm
关键词