MLANA Q16655

被T细胞识别的黑色素瘤抗原1 (MART-1) (抗原 LB39-AA) (抗原 SK29-AA) (蛋白 Melan-A)

功能描述

通过确保GPR143的稳定性参与黑素体生物发生。在黑素细胞蛋白PMEL的表达、稳定性、运输和加工中发挥至关重要的作用，这对于II期黑素体的形成至关重要。 {ECO:0000269|PubMed:15695812, ECO:0000269|PubMed:19717472}。

组织特异性

Expression is restricted to melanoma and melanocyte cell lines and retina.

亚细胞定位

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.