PLK1的有丝分裂相互作用因子和底物 (有丝分裂纺锤体定位蛋白)
PLK1的有丝分裂相互作用因子和底物 (有丝分裂纺锤体定位蛋白)
Q8IVT2功能描述
在有丝分裂纺锤体定向和有丝分裂进程中发挥作用。以PLK1依赖性方式调节dynactin在细胞皮层的分布，从而稳定正确有丝分裂纺锤体定位所需的皮层和星体微管附着。可能将微管连接到肌动蛋白细胞骨架和粘着斑。可能为定向细胞迁移和中心体定向所必需。也可能为高尔基体的正确堆叠所必需。 {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
亚细胞定位
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.
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