MIIP Q5JXC2

迁移和侵袭抑制蛋白 (IGFBP2结合蛋白) (侵袭抑制蛋白45) (IIp45)

功能描述

抑制胶质瘤细胞侵袭，并下调粘附和运动相关基因，如NFKB2和ICAM1。在细胞侵袭方面表现出与IGFBP2相反的作用。 {ECO:0000269|PubMed:14617774}。

组织特异性

Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells.