返回首页

MID1 O15344

E3泛素蛋白连接酶Midline-1 (EC 2.3.2.27) (Midin) (推定转录因子XPRF) (RING指蛋白59) (RING指蛋白Midline-1) (RING型E3泛素转移酶Midline-1) (含三方模体蛋白18)

蛋白质信息 (UniProt)

E3泛素蛋白连接酶Midline-1 (EC 2.3.2.27) (Midin) (推定转录因子XPRF) (RING指蛋白59) (RING指蛋白Midline-1) (RING型E3泛素转移酶Midline-1) (含三方模体蛋白18)

O15344

功能描述

对IGBP1具有E3泛素连接酶活性，促进其单泛素化，导致protein phosphatase PP2A催化亚基去保护，并随后通过多泛素化降解。 {ECO:0000269|PubMed:10400985, ECO:0000269|PubMed:11685209, ECO:0000269|PubMed:22613722}.

组织特异性

In the fetus, highest expression found in kidney, followed by brain and lung. Expressed at low levels in fetal liver. In the adult, most abundant in heart, placenta and brain.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Coiled coil Cytoplasm Cytoskeleton Disease variant Metal-binding Microtubule Phosphoprotein Proteomics identification

外部链接

UniProt: O15344
NCBI Gene