MGST2 Q99735

微粒体谷胱甘肽S-转移酶2 (Microsomal GST-2) (EC 2.5.1.18) (谷胱甘肽过氧化物酶MGST2) (EC 1.11.1.-) (白三烯C4合酶MGST2) (EC 4.4.1.20) (微粒体谷胱甘肽S-转移酶II) (Microsomal GST-II)

功能描述

催化多种不同的谷胱甘肽依赖性反应 (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457)。催化脂质氢过氧化物（如5-HPETE）的谷胱甘肽依赖性还原 (PubMed:23409838, PubMed:9278457)。具有谷胱甘肽转移酶活性，作用于异源亲电试剂，如1-氯-2, 4-二硝基苯 (CDNB) (PubMed:23409838, PubMed:8703034)。亦催化白三烯A4与还原型谷胱甘肽的缀合以形成白三烯C4 (LTC4) (PubMed:23409838, PubMed:26656251)。通过在非免疫细胞中激活LTC4生物合成机制，参与由内质网应激和抗癌药物诱导的氧化DNA损伤 (PubMed:26656251)。 {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:26066610, ECO:0000269|PubMed:26656251, ECO:0000269|PubMed:8703034, ECO:0000269|PubMed:9278457}。

组织特异性

Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034). Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876).

亚细胞定位

Endoplasmic reticulum membrane